TSTMP: Target Selection for human TransMembrane Proteins

The most wanted TMPs for structural genomics

The most wanted list shows, how the human transmembrane proteome could be modeled with the minimum number of steps (i.e. with the smallest number of crystallized proteins). We have sorted the proteins based on how many target homologues they have, then selected the one with the most relative. Then we removed all entries from the list that could be modeled based on the selected protein(s) and iterated this process until every human transmembrane protein were covered.

Number of entries: 335
#IdentifierName#TM segments#TargetTrack#Homologues (targets)Cluster
1 Olfactory receptor 8S171418 (396)0005
2 Tetraspanin-44123 (23)0016
3 Solute carrier family 22 member 712223 (21)0119
4 Putative adhesion G protein-coupled receptor E4P7121 (20)0084
5 Tetraspanin-74018 (18)0016
6 Palmitoyltransferase ZDHHC54014 (14)0055
7 Taste receptor type 2 member 37124 (14)0125
8 Monocarboxylate transporter 412113 (13)0263
9 Probable phospholipid-transporting ATPase VD10113 (13)0035
10 Membrane-spanning 4-domains subfamily A member 154012 (12)0123
... ...

Evidence levels


Target Track statuses

 selected, cloned or expressed
 solubilized or purified
 crystallized or HSQC satisfactory
 XRAY, NMR or ERAY data collected
 model fitted
 in structure database