TSTMP: Target Selection for human TransMembrane Proteins

The list of the most wanted transmembrane proteins shows, how the human transmembrane proteome could be modeled with the minimum number of steps (i.e. with the smallest number of crystallized proteins). We have sorted the proteins based on how many target homologues they have, then selected the one with the most relative. Then we removed all entries from the list that could be modeled based on the selected protein(s) and iterated this process until no human transmembrane protein were left.

The upper figure shows cluster sizes from the most wanted list. The lower figure depicts the cumulative size of number of homologues, i.e. how the coverage of yet unmodeled human transmembrane proteome changes by solving structures from the most wanted list (red), from those proteins that can be found in the TargeTrack database (blue) or from choosing target by chance (orange). According to the graph 1537 and 1721 of the uncharactized proteins could be modeled if the structure of the first 50 and 100 proteins from the list would be solved, respectively (see also Statistics by evidence).